Article
Review article: Pathogenic role of complement activation in anti‐neutrophil cytoplasmic auto‐antibody‐associated vasculitis
1 Feb 2009
Abstract excerpt
SUMMARY: Small-vessel vasculitides associated with anti-neutrophil cytoplasmic auto-antibodies (ANCA) are severe systemic diseases that may affect any organ. Increasing evidence from clinical, animal and in vitro studies indicates that ANCA are causally involved in disease pathogenesis mainly through activation of neutrophils resulting in endothelial cell injury. Recent studies suggest a previously unsuspected...
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