Article

Neutrophils and Platelets as Key Players in the Pathogenesis of ANCA-Associated Vasculitis and Potential Sources of Disease Activity Biomarkers

2025-04-24

Abstract excerpt

Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a heterogeneous group of small-vessel vasculitides characterized by the presence of antibodies binding to myeloperoxidase (MPO) and proteinase-3 (PR3), found in neutrophil granules. Apart from being the target of ANCA, neutrophils actively contribute to the vicious cycle of inflammation and vascular damage in AAV. On the other hand, plate...

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Literature Corpus work: 183306f9-fa06-57ad-88df-238895209228
DOI: 10.20944/preprints202504.2048.v1

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