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Article

Pathophysiology of ANCA-associated vasculitides: are ANCA really pathogenic?

The Netherlands journal of medicine - 1 Dec 2003

Tervaert J W Cohen, Heeringa P

Abstract excerpt

The strong relation between antineutrophil cytoplasmic autoantibodies (ANCA) and primary vasculitic syndromes suggests a pathophysiological role for ANCA. Experimental evidence for the pathogenic potential of ANCA has been derived from in vitro studies that demonstrate that ANCA can activate tumour necrosis factor alpha primed neutrophils, monocytes and/or endothelial cells. The binding of ANCA to primed...

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Share to Antibodies, Antineutrophil Cytoplasmic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15025415

Genes

MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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