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Article

Receptor expression modulates the specificity of transforming growth factor‐β signaling pathways

11 Mar 2009

Abstract excerpt

In current models of transforming growth factor-beta (TGF-beta) family signaling, type II receptors activate specific activin receptor-like kinase (ALK) type I receptors. These serine/threonine kinases activate ligand-dependent receptor regulated (R)-Smad by phosphorylating carboxy-terminal serines. We found that the receptor expression levels affected the phosphorylation and activation of the two R-Smad...

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PMID: 19335617
DOI: 10.1111/j.1365-2443.2009.01283.x

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