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Article

Functional SNPs in HSPA1A gene predict risk of coronary heart disease.

PloS one - 1 Jan 2009

He Meian, Guo Huan, Yang Xiaobo, Zhang Xiaomin, Zhou Li, Cheng Longxian, Zeng Hesong, Hu Frank B, Tanguay Robert M, Wu Tangchun

Abstract excerpt

BACKGROUND: HSP70 plays crucial roles in endothelial cell apoptosis, which is involved in the early phase and progress of coronary heart disease (CHD). However, the association between polymorphisms of HSP70 genes and the risk of CHD still remains unclear. Our aim was to determine whether genetic variants in the HSPA1A gene are associated with the risk of CHD. METHODOLOGY/PRINCIPAL FINDINGS: By resequencing and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19333379
DOI: 10.1371/journal.pone.0004851
PMCID: PMC2659421

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