Article
Genetic polymorphisms in the DNA repair gene XRCC1 and susceptibility to glioma in a Han population in northeastern China: a case-control study.
Gene - 10 Nov 2012
Wang Dianhong, Hu Yongzhen, Gong Haidong, Li Jingwen, Ren Yanhai, Li Guozhong, Liu Aiguo
Abstract excerpt
BACKGROUND: Several single nucleotide polymorphisms (SNPs) in the X-ray cross-complementing group 1 (XRCC1) gene have been shown to influence DNA repair and to modify cancer susceptibility. To investigate the role of these loci further, we examined the association of three XRCC1 polymorphisms with the risk of gliomas in a Han population in northeastern China. METHODS: Using a PCR-RFLP method, XRCC1 Arg194Trp,...
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