Article
Association between combined properdin and mannose-binding lectin deficiency and infection with Neisseria meningitidis.
Molecular immunology - 1 Feb 2006
Bathum Lise, Hansen Heidi, Teisner Børge, Koch Claus, Garred Peter, Rasmussen Kirsten, Wang Palle
Abstract excerpt
BACKGROUND: Individuals genetically deficient of properdin are more susceptible to meningococcal disease. Likewise low concentration or decreased biological activity of mannose-binding lectin (MBL) is associated with higher incidence of bacterial infections during childhood. In this study we report our findings in a Danish family with a remarkably high incidence of meningococcal meningitis-in total four cases,...
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