Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bone marrow failure syndromes: paroxysmal nocturnal hemoglobinuria.

Hematology/oncology clinics of North America - 1 Apr 2009

Parker Charles J

Abstract excerpt

This article discusses the etiology of paroxysmal nocturnal hemoglobinuria (PNH) and its relationship to marrow hyperplasia. The author posits that the defining clinical pathology of PNH (ie, complementmediated intravascular hemolysis) is an epiphenomenon that is a consequence of an orchestrated response (ie, natural selection of PIGA-mutant stem cells) to a specific type of bone marrow injury (ie, immune...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Monoclonal
Share to Antibodies, Monoclonal, Humanized
Share to Bone Marrow Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement System Proteins

Share to Hemoglobinuria, Paroxysmal

Share to Hemolysis

Share to Membrane Proteins

Share to Mutation

Source

Identifiers

PMID: 19327587
DOI: 10.1016/j.hoc.2009.01.014

Genes

PIGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bone marrow failure syndromes: paroxysmal nocturnal hemoglobinuria.PMID 19327587Read ↗

Update on the diagnosis and management of paroxysmal nocturnal hemoglobinuriaSemantic proximity Read ↗

Paroxysmal nocturnal hemoglobinuria: current issues in pathophysiology and treatment.Semantic proximity Read ↗

Paroxysmal Nocturnal Hemoglobinuria: Unraveling Its Molecular Pathogenesis and Advancing Targeted Therapeutic StrategiesSemantic proximity Read ↗

The pathophysiology of disease in patients with paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

Management of paroxysmal nocturnal hemoglobinuria in the era of complement inhibitory therapy.Semantic proximity Read ↗

Complement-driven anemia: more than just paroxysmal nocturnal hemoglobinuriaSemantic proximity Read ↗

Paroxysmal Nocturnal Hemoglobinuria: Biology and TreatmentSemantic proximity Read ↗

Paroxysmal nocturnal haemoglobinuria.Semantic proximity Read ↗

Recent advances in the pathogenesis and treatment of paroxysmal nocturnal hemoglobinuriaSemantic proximity Read ↗

Pathogenesis of paroxysmal nocturnal hemoglobinuriaSemantic proximity Read ↗

[Paroxysmal nocturnal hemoglobinuria].Semantic proximity Read ↗

Recent insights into the pathophysiology of paroxysmal nocturnal hemoglobinuria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.