Article
Differential effects of cardiac sodium channel mutations on initiation of ventricular arrhythmias in patients with Brugada syndrome.
Heart rhythm - 1 Apr 2009
Morita Hiroshi, Nagase Satoshi, Miura Daiji, Miura Aya, Hiramatsu Shigeki, Tada Takeshi, Murakami Masato, Nishii Nobuhiro, Nakamura Kazufumi, Morita Shiho T, Oka Takefumi, Kusano Kengo F, Ohe Tohru
Abstract excerpt
BACKGROUND: Premature ventricular contractions (PVCs) do not occur frequently but can induce ventricular fibrillation (VF) in patients with Brugada syndrome. The effect of SCN5A mutation on the onset of ventricular arrhythmias is unknown. OBJECTIVE: The purpose of this study was to evaluate PVC morphology and onset of VF in patients with Brugada syndrome. METHODS: Morphology of PVCs was evaluated by 12-lead ECG...
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