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Article

Association Between Deleterious SCN5A Variants and Ventricular Septal Defect in Young Patients With Brugada Syndrome.

JACC. Clinical electrophysiology - 1 Mar 2022

Suzuki Keisuke, Sonoda Keiko, Aoki Hisaaki, Nakamura Yuko, Watanabe Seiichi, Yoshida Yoko, Hoshino Kenji, Ozawa Junichi, Imamura Tomohiko, Aiba Takeshi, Kato Koichi, Makiyama Takeru, Kusano Kengo, Horie Minoru, Ohno Seiko

Abstract excerpt

OBJECTIVES: This study aimed to investigate the clinical characteristics of young patients with Brugada syndrome (BrS) with ventricular septal defect (VSD) and explore their genetic backgrounds. BACKGROUND: VSD is the most frequently occurring congenital heart disease among children. In contrast, BrS is a rare hereditary disease that is responsible for ventricular fibrillation and sudden cardiac death. Owing to...

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PMID: 35331424
DOI: 10.1016/j.jacep.2022.01.007

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