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Article

Novel glutaredoxin activity of the yeast prion protein Ure2 reveals a native-like dimer within fibrils.

The Journal of biological chemistry - 22 May 2009

Zhang Zai-Rong, Perrett Sarah

Abstract excerpt

Ure2 is the protein determinant of the Saccharomyces cerevisiae prion [URE3]. Ure2 has structural similarity to glutathione transferases, protects cells against heavy metal and oxidant toxicity in vivo, and shows glutathione-dependent peroxidase activity in vitro. Here we report that Ure2 (which has no cysteine residues) also shows thiol-disulfide oxidoreductase activity similar to that of glutaredoxin enzymes....

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Identifiers

PMID: 19321443
DOI: 10.1074/jbc.M901189200
PMCID: PMC2682854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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