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Article

Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide.

Journal of neurochemistry - 1 Jan 2010

Arciello Mario, Capo Concetta Rosa, Cozzolino Mauro, Ferri Alberto, Nencini Monica, Carrì Maria Teresa, Rossi Luisa

Abstract excerpt

The copper-enzyme cytochrome c oxidase (Cytox) has been indicated as a primary molecular target of mutant copper, zinc superoxide dismutase (SOD1) in familial amyotrophic lateral sclerosis (fALS); however, the mechanism underlying its inactivation is still unclear. As the toxicity of mutant SOD1s...

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Source

Identifiers

PMID: 19845829
DOI: 10.1111/j.1471-4159.2009.06441.x

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19845829-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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