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Article

Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide.

Journal of neurochemistry - 1 Jan 2010

Arciello Mario, Capo Concetta Rosa, Cozzolino Mauro, Ferri Alberto, Nencini Monica, Carrì Maria Teresa, Rossi Luisa

Abstract excerpt

The copper-enzyme cytochrome c oxidase (Cytox) has been indicated as a primary molecular target of mutant copper, zinc superoxide dismutase (SOD1) in familial amyotrophic lateral sclerosis (fALS); however, the mechanism underlying its inactivation is still unclear. As the toxicity of mutant SOD1s could arise from their selective recruitment to mitochondria, it is conceivable that they might compete with Cytox for...

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Source

Identifiers

PMID: 19845829
DOI: 10.1111/j.1471-4159.2009.06441.x

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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