Article
Distribution of MICA diversity in the Chinese Han population by polymerase chain reaction sequence-based typing for exons 2-6.
Tissue antigens - 1 Apr 2009
Zhu F, Zhao H, He Y, Zhang W, He J, Xu X, Yan L
Abstract excerpt
Major histocompatibility complex class I chain-related gene A (MICA) is located 46 kb centromeric to HLA-B locus and encodes a stress-inducible protein. MICA allelic variation is thought to be associated with disease susceptibility and immune response to transplants. In this study, polymerase chain reaction sequence-based typing (PCR-SBT) method for MICA alleles has been established. Genomic DNAs from 100 healthy...
Topics
- Alleles
- Asian People
- China
- Ethnicity
- Exons
- Genetic Variation
- HLA-B Antigens
- Histocompatibility Antigens Class I
- Humans
- Linkage Disequilibrium
- Polymerase Chain Reaction
- Population Groups
