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Article

Quantifying interactions within the NADP(H) enzyme network in Drosophila melanogaster.

Genetics - 1 Jun 2009

Merritt Thomas J S, Kuczynski Caitlin, Sezgin Efe, Zhu Chen-Tseh, Kumagai Seiji, Eanes Walter F

Abstract excerpt

In this report, we use synthetic, activity-variant alleles in Drosophila melanogaster to quantify interactions across the enzyme network that reduces nicotinamide adenine dinucleotide phosphate (NADP) to NADPH. We examine the effects of large-scale variation in isocitrate dehydrogenase (IDH) or glucose-6-phosphate dehydrogenase (G6PD) activity in a single genetic background and of smaller-scale variation in IDH,...

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Identifiers

PMID: 19307608
DOI: 10.1534/genetics.109.100677
PMCID: PMC2691764

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