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Article

De-Novo Identification of PPARγ/RXR Binding Sites and Direct Targets during Adipogenesis

19 Mar 2009

Abstract excerpt

BACKGROUND: The pathophysiology of obesity and type 2 diabetes mellitus is associated with abnormalities in endocrine signaling in adipose tissue and one of the key signaling affectors operative in these disorders is the nuclear hormone transcription factor peroxisome proliferator-activated receptor-gamma (PPARgamma). PPARgamma has pleiotropic functions affecting a wide range of fundamental biological processes...

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PMID: 19300518
DOI: 10.1371/journal.pone.0004907

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