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Immunization against arthropod protein impairs transmission of rickettsial pathogen from ticks to the vertebrate host

30 May 2023

Abstract excerpt

Human anaplasmosis caused by Anaplasma phagocytophilum is one of the most common tick-borne diseases in the United States. The black-legged ticks, Ixodes scapularis, vector and transmit this bacterium to humans. In this study, we provide evidence that targeting I. scapularis membrane-bound organic anion transporting polypeptide 4056 (IsOATP4056) with an anti-vector vaccine affects transmission of A....

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PMID: 37253745
DOI: 10.1038/s41541-023-00678-y

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