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Article

Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm.

Stroke - 1 May 2009

Santiago-Sim Teresa, Mathew-Joseph Sumy, Pannu Hariyadarshi, Milewicz Dianna M, Seidman Christine E, Seidman J G, Kim Dong H

Abstract excerpt

BACKGROUND AND PURPOSE: Familial aggregation of intracranial aneurysms (IA) strongly suggests a genetic contribution to pathogenesis. However, genetic risk factors have yet to be defined. For families affected by aortic aneurysms, specific gene variants have been identified, many affecting the receptors to transforming growth factor-beta (TGF-beta). In recent work, we found that aortic and intracranial aneurysms...

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Source

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Identifiers

PMID: 19299629
DOI: 10.1161/STROKEAHA.108.540245
PMCID: PMC2678560

Genes

ENG
TGFBR3
ACVR1
TGFB1
TGFBR1
TGFBR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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