Article
Nonradioactive heteroduplex tracking assay for the detection of minority-variant chloroquine-resistant Plasmodium falciparum in Madagascar.
Malaria journal - 16 Mar 2009
Juliano Jonathan J, Randrianarivelojosia Milijaona, Ramarosandratana Benjamin, Ariey Frédéric, Mwapasa Victor, Meshnick Steven R
Abstract excerpt
BACKGROUND: Strains of Plasmodium falciparum genetically resistant to chloroquine (CQ) due to the presence of pfcrt 76T appear to have been recently introduced to the island of Madagascar. The prevalence of such resistant genotypes is reported to be low (< 3%) when evaluated by conventional PCR. However, these methods are insensitive to low levels of mutant parasites present in patients with polyclonal...
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