Article
The favorable impact of CEBPA mutations in patients with acute myeloid leukemia is only observed in the absence of associated cytogenetic abnormalities and FLT3 internal duplication.
Blood - 21 May 2009
Renneville Aline, Boissel Nicolas, Gachard Nathalie, Naguib Dina, Bastard Christian, de Botton Stéphane, Nibourel Olivier, Pautas Cécile, Reman Oumedaly, Thomas Xavier, Gardin Claude, Terré Christine, Castaigne Sylvie, Preudhomme Claude, Dombret Hervé
Abstract excerpt
Mutations of the CCAAT/enhancer binding protein alpha (CEBPA) gene have been associated with a favorable outcome in patients with acute myeloid leukemia (AML), but mainly in those with a normal karyotype. Here, we analyzed the impact of associated cytogenetic abnormalities or bad-prognosis fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) in 53 patients with CEBPA(+) de novo AML treated in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.