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Article

Some cardiomyopathy-causing troponin I mutations stabilize a functional intermediate actin state.

Biophysical journal - 18 Mar 2009

Mathur Mohit C, Kobayashi Tomoyoshi, Chalovich Joseph M

Abstract excerpt

We examined four cardiomyopathy-causing mutations of troponin I that appear to disturb function by altering the distribution of thin filament states. The R193H (mouse) troponin I mutant had greater than normal actin-activated myosin-S1 ATPase activity in both the presence and absence of calcium. The rate of ATPase activity was the same as that of the wild-type at near-saturating concentrations of the activator,...

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Identifiers

PMID: 19289050
DOI: 10.1016/j.bpj.2008.12.3909
PMCID: PMC2717271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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