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Article

The bacterial virulence factor lymphostatin compromises intestinal epithelial barrier function by modulating rho GTPases.

The American journal of pathology - 1 Apr 2009

Babbin Brian A, Sasaki Maiko, Gerner-Schmidt Kirsten W, Nusrat Asma, Klapproth Jan-Michael A

Abstract excerpt

Lymphocyte inhibitory factor A (lifA) in Citrobacter rodentium encodes the large toxin lymphostatin, which contains two enzymatic motifs associated with bacterial pathogenesis, a glucosyltransferase and a protease. Our aim was to determine the effects of each lymphostatin motif on intestinal epithelial-barrier function. In-frame mutations of C. rodentium lifA glucosyltransferase (CrGlM21) and protease (CrPrM5)...

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Source

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Identifiers

PMID: 19286565
DOI: 10.2353/ajpath.2009.080640
PMCID: PMC2671366

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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