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Article

A Large Toxin from Pathogenic <i>Escherichia coli</i> Strains That Inhibits Lymphocyte Activation

1 Apr 2000

Abstract excerpt

The mechanisms by which bacteria resist cell-mediated immune responses to cause chronic infections are largely unknown. We report the identification of a large gene present in enteropathogenic strains of Escherichia coli (EPEC) that encodes a toxin that specifically inhibits lymphocyte proliferation and interleukin-2 (IL-2), IL-4, and gamma interferon production in response to a variety of stimuli. Lymphostatin,...

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PMID: 10722613
DOI: 10.1128/iai.68.4.2148-2155.2000

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