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Article

Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo

10 Mar 2009

Abstract excerpt

BACKGROUND: Calorie restriction (CR) produces a number of health benefits and ameliorates diseases of aging such as type 2 diabetes. The components of the pathways downstream of CR may provide intervention points for developing therapeutics for treating diseases of aging. The NAD+-dependent protein deacetylase SIRT1 has been implicated as one of the key downstream regulators of CR in yeast, rodents, and humans....

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PMID: 19284563
DOI: 10.1186/1752-0509-3-31

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