Article
Perioperative treatment of gastrointestinal stromal tumors.
Oncology (Williston Park, N.Y.) - 1 Jan 2009
Fernandes Gustavo dos Santos, Blanke Charles D, Freitas Daniela, Guedes Rodrigo, Hoff Paulo M
Abstract excerpt
This review describes the current multidisciplinary management of gastrointestinal stromal tumor (GIST), which is the most common sarcoma of the gastrointestinal tract. Before 2001, surgery was the only effective therapy for GIST. The discovery of the central role of KIT proto-oncogene mutations in the pathogenesis of this tumor, and the development of specific inhibitors of KIT tyrosine kinase (TK) function, has...
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