Article
Management of Gastrointestinal Stromal Tumour: Current Practices and Visions for the Future.
Oncology - 1 Jan 2015
Blay Jean-Yves, Casali Paolo G, Dei Tos Angelo Paolo, Le Cesne Axel, Reichardt Peter
Abstract excerpt
Gastrointestinal stromal tumour (GIST), while relatively rare, is the most common mesenchymal tumour of the gastrointestinal tract. These tumours are largely resistant to cytotoxic chemotherapy and, in the past, were typically managed surgically. However, as a result of the identification of activating mutations in the proto-oncogene KIT and the development of compounds that inhibit the KIT receptor tyrosine...
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