Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro phenotypic screening of 7-chloro-4-amino(oxy)quinoline derivatives as putative anti-Trypanosoma cruzi agents.

Bioorganic & medicinal chemistry letters - 15 Feb 2014

Fonseca-Berzal Cristina, Rojas Ruiz Fernando A, Escario José A, Kouznetsov Vladimir V, Gómez-Barrio Alicia

Abstract excerpt

In this study, a series of 22 pre-synthesized 7-chloro-4-amino(oxy)quinoline derivatives was assayed in vitro as potential antichagasic agents. A primary screening against Trypanosoma cruzi epimastigotes and a non-specific cytotoxicity assay on murine fibroblasts were simultaneously performed, resulting quinolines 3, 7 and 12 with great selectivity (SI) on the extracellular parasite (SI7, SI3, SI12 and SIBZ...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminoquinolines
Share to Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Evaluation, Preclinical

Share to Fibroblasts

Share to Molecular Structure

Share to Structure-Activity Relationship

Share to Trypanocidal Agents

Share to Trypanosoma cruzi

Source

Identifiers

PMID: 24461296
DOI: 10.1016/j.bmcl.2013.12.071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro phenotypic screening of 7-chloro-4-amino(oxy)quinoline derivatives as putative anti-Trypanosoma cruzi agents.PMID 24461296Read ↗

Optimization of antitrypanosomatid agents: identification of nonmutagenic drug candidates with in vivo activity.Semantic proximity Read ↗

The current drug discovery landscape for trypanosomiasis and leishmaniasis: Challenges and strategies to identify drug targetsSemantic proximity Read ↗

A Brief Review of Drug Discovery Research for Human African TrypanosomiasisSemantic proximity Read ↗

New L-proline uptake inhibitors with anti-Trypanosoma cruzi activitySemantic proximity Read ↗

Phenotypic screening approaches for Chagas disease drug discovery.Semantic proximity Read ↗

Synthesis, Characterisation, Biological Evaluation and In Silico Studies of Quinoline-1,2, 3-Triazole-Anilines as Potential Antitubercular and Anti-HIV AgentsSemantic proximity Read ↗

Exploratory Study of Guanidine Derivatives as Novel Anti <i>Trypanosoma cruzi</i> ScaffoldsSemantic proximity Read ↗

Drug screening and development cascade for Chagas disease: an update of in vitro and in vivo experimental models.Semantic proximity Read ↗

Phenotypic evaluation and in silico ADMET properties of novel arylimidamides in acute mouse models of Trypanosoma cruzi infection.Semantic proximity Read ↗

Targeting Channels and Transporters in Protozoan Parasite InfectionsSemantic proximity Read ↗

Phenotypic Screening of Small Molecules with Antimalarial Activity for Three Different Parasitic Life Stages.Semantic proximity Read ↗

Initial studies on mechanism of action and cell death of active N-oxide-containing heterocycles in Trypanosoma cruzi epimastigotes in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.