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Article

Population genomic analysis of ALMS1 in humans reveals a surprisingly complex evolutionary history.

Molecular biology and evolution - 1 Jun 2009

Scheinfeldt Laura B, Biswas Shameek, Madeoy Jennifer, Connelly Caitlin F, Schadt Eric E, Akey Joshua M

Abstract excerpt

Mutations in the human gene ALMS1 result in Alström Syndrome, which presents with early childhood obesity and insulin resistance leading to Type 2 diabetes. Previous genomewide scans for selection in the HapMap data based on linkage disequilibrium and population structure suggest that ALMS1 was subject to recent positive selection. Through a detailed population genomic analysis of existing genomewide data sets...

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Identifiers

PMID: 19279085
DOI: 10.1093/molbev/msp045
PMCID: PMC2734137

Genes

ALMS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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