Article
Genetic similarity of chromosome 6 between patients receiving hematopoietic stem cell transplantation and HLA matched sibling donors.
Haematologica - 1 Apr 2009
Turpeinen Hannu, Volin Liisa, Nikkinen Lauri, Ojala Pauli, Palotie Aarno, Saarela Janna, Partanen Jukka
Abstract excerpt
BACKGROUND: Matching for HLA genes located on chromosome 6 is required in hematopoietic stem cell transplantation to reduce the incidence of graft-versus-host disease. However, a considerable proportion of patients still suffer from it, obviously due to genetic differences outside the HLA gene region. DESIGN AND METHODS: We studied the similarity of almost 4,000 single nucleotide polymorphisms on chromosome 6...
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