Article
Exploring the Risks of Genetic Similarity Between Donor and Recipient in Human Leukocyte Antigen-Matched Transplantation.
Transplantation proceedings - 1 Apr 2020
Zhen Xi, Wanxin An, Chunling Jiang, Hui Liu
Abstract excerpt
OBJECTIVE: Successful allogeneic hematopoietic stem cell transplantation (HSCT) relies on human leukocyte antigen (HLA) matching. However, whether HLA-matching between donors and recipients increases recipients' risk of genetic disease remains unclear. METHODS: We investigated whether HLA-matched donor cells used for HSCT have similar microsatellite DNA polymorphisms to HSCT recipients at 19 randomly selected...
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