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Article

Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin.

Journal of molecular biology - 17 Apr 2009

Zheng Jianting, Sagar Vatsala, Smolinsky Adam, Bourke Chase, LaRonde-LeBlanc Nicole, Cropp T Ashton

Abstract excerpt

The regulatory protein MphR(A) has recently seen extensive use in synthetic biological applications, such as metabolite sensing and exogenous control of gene expression. This protein negatively regulates the expression of a macrolide 2'-phosphotransferase I resistance gene (mphA) via binding to a 35-bp DNA operator upstream of the start codon and is de-repressed by the presence of erythromycin. Here, we present...

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Identifiers

PMID: 19265703
DOI: 10.1016/j.jmb.2009.02.058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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