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Article

Nitric oxide deficiency determines global chromatin changes in Duchenne muscular dystrophy

5 Mar 2009

Abstract excerpt

ABSTRACT The present study provides evidence that abnormal patterns of global histone modification are present in the skeletal muscle nuclei of mdx mice and Duchenne muscular dystrophy (DMD) patients. A combination of specific histone H3 modifications, including Ser‐10 phosphorylation, acetylation of Lys 9 and 14, and Lys 79 methylation, were found enriched in muscle biopsies from human patients affected by DMD...

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PMID: 19264835
DOI: 10.1096/fj.08-115618

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