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Skeletal Muscle Possesses an Epigenetic Memory of Exercise: Role of Nucleus Type-Specific DNA Methylation

1 Jan 2021

Abstract excerpt

The recent paper in Function by Wen et al.,1 adds exciting new knowledge to earlier evidence that human skeletal muscle possesses an epigenetic memory of exercise.2–4 These works demonstrated retained methylation signatures on the DNA from skeletal muscle tissue following earlier training-induced muscle hypertrophy, that was maintained even during detraining when exercise had completely ceased, and lean mass had...

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PMID: 35330953
DOI: 10.1093/function/zqab047

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