Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PCNA monoubiquitylation and DNA polymerase eta ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae.

Nucleic acids research - 1 May 2009

van der Kemp Patricia Auffret, de Padula Marcelo, Burguiere-Slezak Guenaelle, Ulrich Helle D, Boiteux Serge

Abstract excerpt

7,8-Dihydro-8-oxoguanine (8-oxoG) is an abundant and mutagenic DNA lesion. In Saccharomyces cerevisiae, the 8-oxoG DNA N-glycosylase (Ogg1) acts as the primary defense against 8-oxoG. Here, we present evidence for cooperation between Rad18-Rad6-dependent monoubiquitylation of PCNA at K164, the da...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed DNA Polymerase
Share to DNA Glycosylases
Share to DNA Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine

Share to Mutagenesis

Share to Proliferating Cell Nuclear Antigen

Share to Ubiquitin

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 19264809
DOI: 10.1093/nar/gkp105
PMCID: PMC2677869

Genes

PCNA
PIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19264809-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PCNA monoubiquitylation and DNA polymerase eta ubiquitin-binding domain are required to prevent 8-oxoguanine-induced mutagenesis in Saccharomyces cerevisiae.PMID 19264809Read ↗

The post-replication repair RAD18 and RAD6 genes are involved in the prevention of spontaneous mutations caused by 7,8-dihydro-8-oxoguanine in Saccharomyces cerevisiae.Semantic proximity Read ↗

A role for PCNA ubiquitination in immunoglobulin hypermutation.Semantic proximity Read ↗

Multiple DNA glycosylases for repair of 8-oxoguanine and their potential in vivo functions.Semantic proximity Read ↗

A novel function of DNA polymerase zeta regulated by PCNA.Semantic proximity Read ↗

Constitutive fusion of ubiquitin to PCNA provides DNA damage tolerance independent of translesion polymerase activities.Semantic proximity Read ↗

Mms2-Ubc13-dependent and -independent roles of Rad5 ubiquitin ligase in postreplication repair and translesion DNA synthesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

PCNA Modifications for Regulation of Post-Replication Repair PathwaysSemantic proximity Read ↗

The polymerase eta translesion synthesis DNA polymerase acts independently of the mismatch repair system to limit mutagenesis caused by 7,8-dihydro-8-oxoguanine in yeast.Semantic proximity Read ↗

Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164 SUMOylation and ubiquitination.Semantic proximity Read ↗

Reversal of PCNA ubiquitylation by Ubp10 in Saccharomyces cerevisiae.Semantic proximity Read ↗

Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae.Semantic proximity Read ↗

The translesion DNA polymerases Pol ζ and Rev1 are activated independently of PCNA ubiquitination upon UV radiation in mutants of DNA polymerase δ.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.