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Article

Interstrand side chain--side chain interactions in a designed beta-hairpin: significance of both lateral and diagonal pairings.

Journal of the American Chemical Society - 12 Sept 2001

Syud F A, Stanger H E, Gellman S H

Abstract excerpt

The contributions of interstrand side chain-side chain contacts to beta-sheet stability have been examined with an autonomously folding beta-hairpin model system. RYVEV(D)PGOKILQ-NH2 ((D)P = D-proline, O = ornithine) has previously been shown to adopt a beta-hairpin conformation in aqueous solution, with a two-residue loop at D-Pro-Gly. In the present study, side chains that display interstrand NOEs (Tyr-2,...

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Identifiers

PMID: 11535071
DOI: 10.1021/ja0109803

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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