Article
JAK2V617F mutations in myeloid malignancies: single center experience.
Prilozi - 1 Dec 2008
Panovska-Stavridis Irina, Cevreska L, Ivanovski M, Stojanovik A, Lozance M, Matevska N, Dimovski A, Serafimoski V
Abstract excerpt
Recently, V617F mutation in JAK2 tyrosine kinase gene was established as a marker of myeloproliferation, useful for proving clonality and securing diagnosis in a considerable proportion of the myeloproliferative neoplasms (MPN) The discovery presents a major breakthrough in the understanding of the pathogenesis of the MPN. Moreover, some studies suggest a possible role of the JAK2V617F mutation in the...
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