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Article

BCR and TLR signaling pathways are recurrently targeted by genetic changes in splenic marginal zone lymphomas.

Haematologica - 1 Apr 2012

Yan Qingguo, Huang Yuanxue, Watkins A James, Kocialkowski Sylvia, Zeng Naiyan, Hamoudi Rifat A, Isaacson Peter G, de Leval Laurence, Wotherspoon Andrew, Du Ming-Qing

Abstract excerpt

The genetics and pathogenesis of splenic marginal zone lymphoma are poorly understood. The lymphoma lacks chromosome translocation, and approximately 30% of cases are featured by 7q deletion, but the gene targeted by the deletion is unknown. A recent study showed inactivation of A20, a "global" NF-κB negative regulator, in 1 of 12 splenic marginal zone lymphomas. To investigate further whether deregulation of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloid Differentiation Factor 88

Share to Receptors, Antigen, B-Cell

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Source

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Identifiers

PMID: 22102703
DOI: 10.3324/haematol.2011.054080
PMCID: PMC3347666

Genes

BCR
MYD88
CARD11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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