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Article

Loss of miR-449a in ERG-associated prostate cancer promotes the invasive phenotype by inducing SIRT1.

Oncotarget - 19 Apr 2016

Kumar Parameet, Sharad Shashwat, Petrovics Gyorgy, Mohamed Ahmed, Dobi Albert, Sreenath Taduru L, Srivastava Shiv, Biswas Roopa

Abstract excerpt

Epigenetic regulation by SIRT1, a multifaceted NAD+-dependent protein deacetylase, is one of the most common factors modulating cellular processes in a broad range of diseases, including prostate cancer (CaP). SIRT1 is over-expressed in CaP cells, however the associated mechanism is not well unde...

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Topics

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Share to Cell Line, Tumor
Share to Gene Expression Regulation, Neoplastic
Share to MicroRNAs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Invasiveness

Share to Phenotype

Share to Prostatic Neoplasms

Share to Sirtuin 1

Share to Transcriptional Regulator ERG

Source

Open in PubMed Open full text

Identifiers

PMID: 26988912
DOI: 10.18632/oncotarget.8061
PMCID: PMC5008401

Genes

ERG
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-26988912-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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