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Article

Modification by two genes of associations between general somatic health and incident depressive syndrome in older people.

Psychosomatic medicine - 1 Apr 2009

Kim Jae-Min, Stewart Robert, Kim Sung-Wan, Yang Su-Jin, Shin Il-Seon, Yoon Jin-Sang

Abstract excerpt

OBJECTIVE: To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high frequencies of potential risk alleles. METHODS: With a 2-year prospective study of a community...

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PMID: 19251870
DOI: 10.1097/PSY.0b013e3181990fff

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MTHFR

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