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Article

The Interplay of Genetics, Behavior, and Pain with Depressive Symptoms in the Elderly.

The Gerontologist - 1 Jun 2015

Klinedinst N Jennifer, Resnick Barbara, Yerges-Armstrong Laura M, Dorsey Susan G

Abstract excerpt

PURPOSE OF STUDY: About 25% of older adults suffer from depressive symptoms. Commonly studied candidate genes associated with depression include those that influence serotonin (SLC6A4), dopamine (COMT), or neuroplasticity (BDNF, NTRK3). However, the majority of candidate gene studies do not consider the interplay of genetics, demographic, clinical, and behavioral factors and how they jointly contribute to...

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Source

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Identifiers

PMID: 26055783
DOI: 10.1093/geront/gnv015
PMCID: PMC4566914

Genes

NTRK3
BDNF
COMT
SLC6A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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