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Article

Modulation of pulmonary vascular smooth muscle cell phenotype in hypoxia: role of cGMP-dependent protein kinase.

American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2007

Zhou Weilin, Dasgupta Chiranjib, Negash Sewite, Raj J Usha

Abstract excerpt

Chronic hypoxia triggers pulmonary vascular remodeling, which is associated with a modulation of the vascular smooth muscle cell (SMC) phenotype from a contractile, differentiated to a synthetic, dedifferentiated state. We previously reported that acute hypoxia represses cGMP-dependent protein ki...

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Share to Cyclic GMP-Dependent Protein Kinases
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Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Muscle, Smooth, Vascular

Share to Pulmonary Veins

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Source

Identifiers

PMID: 17322285
DOI: 10.1152/ajplung.00143.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17322285-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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