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Article

Type of SCN5A mutation determines clinical severity and degree of conduction slowing in loss-of-function sodium channelopathies.

Heart rhythm - 1 Mar 2009

Meregalli Paola G, Tan Hanno L, Probst Vincent, Koopmann Tamara T, Tanck Michael W, Bhuiyan Zahurul A, Sacher Frederic, Kyndt Florence, Schott Jean-Jacques, Albuisson J, Mabo Philippe, Bezzina Connie R, Le Marec Herve, Wilde Arthur A M

Abstract excerpt

BACKGROUND: Patients carrying loss-of-function SCN5A mutations linked to Brugada syndrome (BrS) or progressive cardiac conduction disease (PCCD) are at risk of sudden cardiac death at a young age. The penetrance and expressivity of the disease are highly variable, and new tools for risk stratific...

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Identifiers

PMID: 19251209
DOI: 10.1016/j.hrthm.2008.11.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19251209-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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