Article
Epigallocatechin-3-gallate (EGCG) consumption in the Ts65Dn model of Down syndrome fails to improve behavioral deficits and is detrimental to skeletal phenotypes.
Physiology & behavior - 1 Aug 2017
Stringer Megan, Abeysekera Irushi, Thomas Jared, LaCombe Jonathan, Stancombe Kailey, Stewart Robert J, Dria Karl J, Wallace Joseph M, Goodlett Charles R, Roper Randall J
Abstract excerpt
Down syndrome (DS) is caused by three copies of human chromosome 21 (Hsa21) and results in phenotypes including intellectual disability and skeletal deficits. Ts65Dn mice have three copies of ~50% of the genes homologous to Hsa21 and display phenotypes associated with DS, including cognitive deficits and skeletal abnormalities. DYRK1A is found in three copies in humans with Trisomy 21 and in Ts65Dn mice, and is...
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