Article
Mutational analysis of JAK1 gene in human hepatocellular carcinoma.
Neoplasma - 1 Jan 2009
Xie H J, Bae H J, Noh J H, Eun J W, Kim J K, Jung K H, Ryu J C, Ahn Y M, Kim S Y, Lee S H, Yoo N J, Lee J Y, Park W S, Nam S W
Abstract excerpt
UNLABELLED: The <em>Janus kinase 1</em> (JAK1) gene encodes a cytoplasmic tyrosine kinase that is noncovalently associated with a variety of cytokine receptors and plays a nonredundant role in cell proliferation, survival, and differentiation. The mutated forms of JAK1 often altered the activation of JAK1 and then changed the activation of JAK1/STAT pathways, and this may contribute to cancer development and...
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