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Article

Epstein-Barr virus nuclear protein EBNA3C residues critical for maintaining lymphoblastoid cell growth.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2009

Maruo Seiji, Wu Yi, Ito Taku, Kanda Teru, Kieff Elliott D, Takada Kenzo

Abstract excerpt

Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA3C) is essential for efficient conversion of primary human B lymphocytes to lymphoblastoid cell lines (LCLs) and for continued LCL growth. We used a transcomplementation assay in the context of LCLs transformed by an EBV with a conditional EBNA3C to identify the EBNA3C amino acids (aa) necessary for maintaining LCL growth. Surprisingly, we found that most EBNA3C aa...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Viral

Share to Epstein-Barr Virus Nuclear Antigens

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Share to Immunoglobulin J Recombination Signal Sequence-Binding Protein

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Source

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Identifiers

PMID: 19237563
DOI: 10.1073/pnas.0813134106
PMCID: PMC2657407

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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