Article

Placental uptake and metabolism of 25(OH)Vitamin D determines its activity within the fetoplacental unit

2021-03-01

Abstract excerpt

Pregnancy 25-hydroxyvitamin D (25(OH)D) concentrations are associated with maternal and fetal health outcomes. Using physiological human placental perfusion and villous explants, we investigate the role of the placenta in regulating the relationships between maternal 25(OH)D and fetal physiology. We demonstrate active placental uptake of 25(OH)D3 by endocytosis, placental metabolism of 25(OH)D3 into 24,25-dihydrox...

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Literature Corpus work: 390d207c-f44e-5636-ac5d-8d987b6fd535
DOI: 10.1101/2021.03.01.431439

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