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Article

Connexin26 deafness associated mutations show altered permeability to large cationic molecules.

American journal of physiology. Cell physiology - 1 Oct 2008

Meşe Gülistan, Valiunas Virginijus, Brink Peter R, White Thomas W

Abstract excerpt

Intercellular communication is important for cochlear homeostasis because connexin26 (Cx26) mutations are the leading cause of hereditary deafness. Gap junctions formed by different connexins have unique selectivity to large molecules, so compensating for the loss of one isoform can be challenging in the case of disease causing mutations. We compared the properties of Cx26 mutants T8M and N206S with wild-type...

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Identifiers

PMID: 18684989
DOI: 10.1152/ajpcell.00008.2008
PMCID: PMC2575827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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