Article
[Drug sensitivity in Mycobacterium tuberculosis versus its viability, cytotoxicity, genotype, and the course of the process in patients with pulmonary tuberculosis].
Problemy tuberkuleza i boleznei legkikh - 1 Jan 2008
Manicheva O A, Lasunskaia E B, Zhuravlev V Iu, Otten T F, Barnaulov A O, Mokrousov I V, Pavlova M V, Vishnevskiĭ B I, Narvskaia O V
Abstract excerpt
The authors studied drug sensitivity, mutations in the katG, in-hA, alpC, rpoB genes, virulence via the cytotoxicity test on THP-1 cells, and the viability and genetic affiliation of 53 clinical M. tuberculosis isolates versus data on the form and dynamics of a process. Sensitive and resistant strains did not significantly differ in viability and cytotoxicity. The highest death of infected macrophages was...
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