ras mutation and platinum resistance in human ovarian carcinomas in vitro.

doi:10.1002/(sici)1097-0215(19980703)77:1<94::aid-ijc15>3.0.co;2-9

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Article

ras mutation and platinum resistance in human ovarian carcinomas in vitro.

International journal of cancer - 3 Jul 1998

Holford J, Rogers P, Kelland L R

Abstract excerpt

A panel of 16 human ovarian carcinoma cell lines comprising cisplatin naive as well as those with acquired cisplatin resistance was studied to determine if there was a relationship between ras status and cisplatin sensitivity. From the ras expression studies alongside data produced by direct DNA...

Topics

Carcinoma
Drug Resistance, Neoplasm
Female
Genes, ras
Humans
Mutation
Ovarian Neoplasms
Platinum
Tumor Cells, Cultured

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