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Live cell microscopy analysis of radiation-induced DNA double-strand break motion

12 Feb 2009

Abstract excerpt

We studied the spatiotemporal organization of DNA damage processing by live cell microscopy analysis in human cells. In unirradiated U2OS osteosarcoma and HeLa cancer cells, a fast confined and Brownian-like motion of DNA repair protein foci was observed, which was not altered by radiation. By analyzing the motional activity of GFP-53BP1 foci in live cells up to 12-h after irradiation, we detected an additional...

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PMID: 19221031
DOI: 10.1073/pnas.0810987106

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