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Article

Long-term evolution of the CAZY glycosyltransferase 6 (ABO) gene family from fishes to mammals—a birth-and-death evolution model

13 Feb 2007

Abstract excerpt

Functional glycosyltransferase 6 (GT6) family members catalyze the transfer of galactose or N-acetylgalactosamine in alpha1,3 linkage to various substrates and synthesize structures related to the A and B histo-blood group antigens, the Forssman antigen, alphaGal epitope, and iGb3 glycolipid. In rat, mouse, dog, and cow genomes, we have identified three new mammalian genes (GT6m5, GT6m6, and GT6m7) encoding...

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PMID: 17298992
DOI: 10.1093/glycob/cwm016

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